KALEY Cuoco has revealed Harley Quinn ‘is gonna need calamine lotion’ after her lesbian romps with Poison Ivy.
The former Big Bang Theory actress voices the anti-hero in the Harley Quinn animated series, which has just returned for a second season.
The episodes see Harley and her BFF Poison Ivy become more than friends, and appearing on US chat show Conan via video link, Kaley couldn't help but make a crude joke about their relationship.
The 34-year-old quipped: "Let me put it this way: Harley’s gonna need some calamine lotion.
She added: "That was a funny joke! I just thought of that off the top of my head."
In case her joke needs explaining, calamine lotion is used to treat the effects or symptoms of poison ivy.
The lesbian romance was first teased in a trailer for the second season, before show runner Patrick Schumacker confirmed it earlier this month.
Speaking to , he said: "It will develop more, and it’s definitely going to evolve into, I think, what a lot of people are hoping it will.
"What I can say is, we wanted to do it – it was always on the table. It’s something that had been done in the comments.
"It felt interesting to us or felt like, maybe even important to us, to do it."
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However the team were keen to let the LGBT relationship develop naturally, and not just shoehorn it into the plot for cheap kicks.
Patrick explained how they chose not to do it in the first season as Harley was "just getting out of an abusive relationship" with Joker.
He added: "What would that say about the character if the first story that we tell is about her being in a relationship with somebody else?"
Harley Quinn season two airs on DC Universe, before airing in the UK in May.