Spurs are handing every fan in attendance a special commemorative gift bag and flag to celebrate the occasion.
But Tottenham followers were keen to get there early before the 4.30pm kick-off against the Red Devils and soak up every last moment of the Lane’s unique atmosphere.
Next season they will play all of their home matches at Wembley Stadium while construction work continues.
Their new stadium is set to become one of the most advanced in Europe.
It will feature a retractable pitch and the biggest single-tier stand in the UK – with an impressive 17,000 home end that has been inspired by Borussia Dortmund’s Yellow Wall.
Windows will be installed in the tunnel to allow visitors to watch the players emerge and there will be heated seats behind the dug-out.