AstraZeneca Covid vaccine now suspended in Netherlands as Oxford scientists say ‘no link’ to blood clots

THE NETHERLANDS has joined a growing list of countries which have suspended the AstraZeneca Covid vaccine over fatal blood clot fears.

But a leading Oxford professor who helped develop the jab said there has so far been no proven link to the side effect.

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Professor Andrew Pollard, director of the Oxford vaccine group, said “safety is clearly absolutely paramount”, and no link had been found between the vaccine and blood clots.

He told BBC Radio 4’s Today programme it was “important to understand that a lot of stuff happens to people all the time in normal times".

He added: "In the case of blood clots here in the UK, we see about 3,000 cases of blood clots happening every month.

“So, when you then put a vaccination campaign on top of that, clearly those blood clots still happen and you’ve got to then try and separate out whether, when they occur, they are at all related to the vaccine or not.”

The Prof said more than 11 million doses had now been given in the UK.

The UK medicine regulator the Medicines and Healthcare products Regulatory Agency (MHRA) said they are "not seeing any increase in the number of cases of blood clots” over what they would see normally.

Finland has also done a “very careful study” and have not found an increased risk, Prof Pollard added.

“I think at this moment we’ve got the most data from the UK, which looks very reassuring, but of course it’s absolutely right that there’s careful monitoring of safety and this gets looked into.”

Several European countries have already temporarily suspended use of the jabs, including Germany, Denmark, Austria and Norway, as well as Thailand.

This weekend Ireland chose to "temporarily suspend" the jab as a "precautionary step".

It came after a small number of reports of people experiencing blood clots in the days and weeks after their vaccination.

The European Medicines Agency (EMA) said Austria had paused use after a death, with Denmark and Italy both reporting a fatality.

There were reports of serious clotting in adults in Norway which left four people in hospital.

But so far there is no evidence the events were caused by the vaccine, and countries have halted vaccine rollouts as a precuation.

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AstraZeneca, EU regulators and the World Health Organisation have all rebuffed the blood clot fears.

Dr Phil Bryan, vaccines safety lead at the Medicines and Healthcare products Regulatory Agency, said people “should still go and get their Covid-19 vaccine when asked to do so”.

Dr Bryan said: “We are aware of the action in Ireland.

“We are closely reviewing reports but given the large number of doses administered, and the frequency at which blood clots can occur naturally, the evidence available does not suggest the vaccine is the cause.

“People should still go and get their Covid-19 vaccine when asked to do so.”

The Netherlands joined a fast-growing list of countries to pause the use of AstraZeneca’s on Sunday.

The vaccine will not be used until at least March 29 as a precaution, the Dutch government said in a statement.

The announcement will lead to delays in rolling out shots in the Netherlands, which had pre-ordered 12 million doses of the AZ jab.

Around 290,000 injections in the coming two weeks will have to be cancelled.

The move was based on reports from Denmark and Norway of possible serious side effects, the government said.

No such cases had been found yet in the Netherlands, the Dutch Health ministry said.

“We can’t allow any doubts about the vaccine,” Dutch Health minister Hugo de Jonge said.

“We have to make sure everything is right, so it is wise to pause for now.”

Expected levels of blood clots

Experts say the number of people who have got blood clots after having the jab is comparable to in the general population, meaning there is no clear increased risk.

Professor Anthony Harnden, deputy chairman of the Joint Committee on Vaccination and Immunisation, said there was "no demonstrable difference" between the general population and the 11 million who have so far received the AZ jab to date.

He said: "We have to remember that there are 3,000 blood clots a month on average in the general population and because we're immunising so many people, we are bound to see blood clots at the same time as the vaccination, and that's not because they are due to the vaccination. That's because they occur naturally in the population.

"One ought to also remember that Covid causes blood clots. So, the risks of not having the Covid vaccination far outweigh the risks from the vaccinations."

The EMA - which is conducting the investigation into blood clots in Euopeans who have had the jab - has said the vaccine’s benefits continue to outweigh its risks.

It said the jabs can keep being administered while it carries out a review into any incidents of blood clots.

There had only been 30 cases reported among almost five million people jabbed in Europe as of March 10.

The number of cases of blood clots reported is lower than the hundreds of cases that would be expected among the general population, according to  AstraZeneca’s chief medical officer Ann Taylor.

The pharma giant said its review had found no evidence of an increased risk of pulmonary embolism, deep vein thrombosis (DVT) or thrombocytopenia.

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Dr Taylor said: “Around 17 million people in the EU and UK have now received our vaccine, and the number of cases of blood clots reported in this group is lower than the hundreds of cases that would be expected among the general population.

“The nature of the pandemic has led to increased attention in individual cases and we are going beyond the standard practices for safety monitoring of licensed medicines in reporting vaccine events, to ensure public safety.”